| rdf:type | <https://jpsearch.go.jp/term/type/図書> |
| rdfs:label | "LC-NMR : expanding the limits of structure elucidation" |
| schema:name | "LC-NMR : expanding the limits of structure elucidation" @en |
| ns0:accessInfo | #accessinfo |
| ns0:agential 3 | _:vb66470014 (an orphan bnode) |
| ns0:agential | _:vb66470012 (an orphan bnode) |
| ns0:agential | _:vb66470013 (an orphan bnode) |
| ns0:partOf | _:vb66470015 (an orphan bnode) |
| ns0:sourceInfo | #sourceinfo |
| ns0:spatial | _:vb66470016 (an orphan bnode) |
| ns0:temporal | _:vb66470017 (an orphan bnode) |
| schema:about 4 | <https://jpsearch.go.jp/term/keyword/SCIENCE_Spectroscopy_Spectrum_Analysis_bisacsh> |
| schema:about | <https://jpsearch.go.jp/term/keyword/SCIENCE_Chemistry_Industrial_Technical_bisacsh> |
| schema:about | <https://jpsearch.go.jp/term/keyword/Liquid_chromatography> |
| schema:about | <https://jpsearch.go.jp/term/keyword/SCIENCE_Research_Methodology_bisacsh> |
| schema:creator 2 | <https://ld.webcatplus.jp/entity/C2456515> |
| schema:creator | <https://jpsearch.go.jp/entity/ncname/Gonnella_Nina_C.> (➜ "Gonnella Nina C.") |
| schema:datePublished | "2013" |
| schema:description 5 | "資料種別: Hardback" |
| schema:description | "備考: The isolation and structural characterization of substances present at very low concentrations, as is necessary to satisfy regulatory requirements for pharmaceutical drug degradants and impurities, can present scientific challenges. The coupling of HPLC with NMR spectroscopy has been at the forefront of cutting-edge technologies to address these issues. LC-NMR: Expanding the Limits of Structure Elucidation presents a comprehensive overview of key concepts in HPLC and NMR that are required to achieve definitive structure elucidation with very low levels of analytes. Because skill sets from both of these highly established disciplines are involved in LC-NMR, the author provides introductory background to facilitate readers' proficiency in both areas, including an entire chapter on NMR theory. This book provides guidance in setting up LC-NMR systems, discussion of LC methods that are compatible with NMR, and an update on recent hardware and software advances for system performance, such as improvements in magnet design, probe technology, and solvent suppression techniques that enable unprecedented mass sensitivity in NMR. It also describes numerous NMR collection strategies, including continuous flow, stop flow, solid phase extraction (SPE), loop collection, and capillary electrophoresis. In addition, the author presents an overview of NMR experiments and techniques used in structure elucidation. The text focuses on current developments in chromatographic-NMR integration, with particular emphasis on utility in the pharmaceutical industry. Applications include trace analysis, analysis of mixtures, and detection of degradation products, impurities, metabolites, peptides, and more. The text discusses novel uses and emerging technologies that challenge detection limits as well future directions for this important technique. This book is a practical primary resource for NMR structure determination-including theory and application-that guides the reader through the steps required for isolation and NMR structure elucidation on the micro scale. (Nielsen Book)...(more)" |
| schema:description | "注記: Includes bibliographical references and index" |
| schema:description | "責任表示: Nina C. Gonnella" |
| schema:description | "分類: LCC:QD79.C454; DC23:543/.84; BIC:PNFL2" |
| schema:encodingFormat | <https://ld.webcatplus.jp/ext/code/onix#BB> |
| schema:genre | <https://id.loc.gov/authorities/classification/QD79.C454> |
| schema:inLanguage | <http://id.loc.gov/vocabulary/iso639-2/eng> (➜ "英語") |
| schema:isPartOf | <https://ld.webcatplus.jp/data/5090457> |
| schema:isbn | "9781439875063" |
| schema:numberOfPages | "xvii, 283 p., [8] p. of plates" |
| schema:publisher | <https://ld.webcatplus.jp/entity/P713871> |
| schema:size | "24 cm" |
| schema:spatial | <https://jpsearch.go.jp/entity/place/アメリカ> |
| schema:temporal | <https://jpsearch.go.jp/entity/time/2013> (➜ "2013年") |
| schema:tocEntry | "Introduction to LC-NMR Historical Review Flow and NMR Setting Up the LC-NMR System Solvent Requirements in LC-NMR Solvent Suppression and Referencing The Deuterium Lock The Solvent-Gradient Ramp Diffusion Shimming Acquisition Parameters Chemical-Shift Tracking Other Considerations Sources of Error Summary References NMR Theory Magnetic Properties of Nuclei Data Acquisition Relaxation of Nuclei The Chemical Shift Spin Coupling Nuclear Overhauser Effect (NOE) Coupling of HPLC with NMR References Separation Methods Modes of Separation General Method Development Strategies Column Packing Types Detector Selection RPC Method Development and Compatibility with NMR Integration of CE and NMR Transitioning from Analytical to Preparative Chromatography General Considerations References NMR Instrumentation and Probe Technologies Instrumentation Configuration The Magnet Room Temperature Flow Probe Microcapillary Probes (Room Temperature) Cryogenically Cooled Probes Probe Coil Geometries Probe Sensitivity Comparison References NMR-Associated Isolation Technologies Stopped Flow Loop Collector Solid-Phase Extraction (SPE) Nonchromatographic Flow NMR Direct-Injection NMR (DI-NMR) Capillary Electrophoresis and NMR References NMR Experiments Solvent Suppression Structure Elucidation Experiments NOE Experiments References Applications Degradation Products Impurities Trace Analysis Analysis of Mixtures Tautomer Kinetics Unstable Products Metabolites CE Isolates Natural Products Proteins/Peptides References Other Specialized-Flow NMR NMR and Parallel Detection Data Processing and Deconvolution of Parallel Data Parallel Probe Construction Microprobes Advancements in Multiple-Coil Probe Design Biological Screening and Flow NMR NMR and Microreactors Signal-to-Noise Ratio (Microcoils) Microprobe Design (Microcoil/Microslot/Microstrip) Future Directions Summary References Glossary Index...(more)" |